Men whose brothers have aggressive prostate cancer at increased risk
Men whose brothers had non-low-risk
prostate cancer faced a significantly increased risk for developing an
aggressive form of the malignancy, according to results of a study conducted in
Sweden.
Men with one or two first-degree
relatives with prostate cancer have a two- to fivefold increased risk [for]
being diagnosed with prostate cancer compared with men with no family history
of prostate cancer, and the risk is also increased among men with second- and
third-degree relatives with prostate cancer. Previous twin studies have
assessed the concordance of a prostate cancer diagnosis but not the concordance
of the type of prostate cancer. “If
there is prognostic concordance within families, then knowledge of tumor
characteristics and disease development among relatives may be helpful when
counseling men with suspected or newly diagnosed prostate cancer.”
The researchers used the Swedish Prostate
Cancer Database to identify 4,262 sets of brothers who both were diagnosed with
prostate cancer. Jansson and colleagues categorized cancers as either low risk
(Gleason score, 6 or lower; clinical stage, T1 to T2; PSA, 10 ng/mL or less) or
non-low risk. They used logistic regression to calculate odds ratios for
concordance of non-low-risk cancer among monozygotic twins, dizygotic twins,
full brothers and half brothers.After adjusting for year of diagnosis and age, the highest concordance of non-low-risk disease occurred among monozygotic twins (OR = 3.82; 95% CI, 0.99-16.72). Full brothers also had a significant concordance (OR = 1.21; 95% CI, 1.04-1.39). These results persisted when researchers restricted analysis to brothers diagnosed within 4 years of each other.
Monozygotic twins had a significantly shorter median time between diagnoses than other groups (1.1 years) than full brothers (3.2 years; P < .001), dizygotic twins (2.8 years; P < .014), paternal half brothers (4.1 years; P < .001) and maternal half brothers (3 years; P < .003). The results suggest that a man whose brother has been diagnosed with a non-low-risk prostate cancer is at a clinically relevant increased risk for] developing an aggressive prostate cancer himself.
https://www.healio.com/hematology-oncology/prostate-cancer/news/in-the-journals/%7B6ae1a9af-356a-4699-ab69-44d7ae3c119f%7D/men-whose-brothers-have-aggressive-prostate-cancer-at-increased-risk
No comments:
Post a Comment