Paget disease
of the breast is an uncommon disease, accounting for about 1% to 4% of all
breast malignancies. It occurs most commonly in postmenopausal females, with a
mean age of onset at 57 years. The disease presents as a solitary erythematous,
slightly infiltrated patch on the breast; specifically, the lesion most often
begins on the nipple, and then extends sequentially to the areola and finally
to surrounding skin. As evidenced by this case, the nipple does not have to be
involved. Serous drainage, crust, and scab formation and complaints of pain or
itching are all frequent. Advanced lesions present as deeper red, polycyclic
plaques. In short, Paget disease of the breast closely mimics eczema. In
long-standing lesions, erosion or ulceration, and/or retraction of the nipple
may occur. Paget disease of the breast is nearly always unilateral. Mammary
Paget disease is associated with CANCER (either an in situ or an invasive
ductal carcinoma) in some 92% to 100% of cases.
Source:
Cancernetwork.com
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