New mutation linked to ovarian cancer can be passed down through dad

A newly identified mutation, passed down through the X-chromosome, is linked to earlier onset of ovarian cancer in women and prostate cancer in father and sons

A newly identified mutation, passed down through the X-chromosome, is linked to earlier onset of ovarian cancer in women and prostate cancer in father and sons. Kunle Odunsi, Kevin H. Eng and colleagues at Roswell Park Comprehensive Cancer Center in Buffalo, New York, report these findings February 15th, 2018, in PLOS Genetics.

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Fig 1. X-linked model. Schema for X-linked inheritance when cancer status is specific to women (all carrier men are effectively disease censored). Two family patterns with a pair of first-degree affected women are the maternal grandmother (MGM) family and the paternal grandmother (PGM) family. Stratton's paradox implies that PGM families are more likely under X-linkage because a father must pass the variant to all of his daughters. The rates are equal if the variant is autosomal.

Credit: Kevin H. Eng and colleagues

https://www.sciencedaily.com/releases/2018/02/180215141758.htm