Anti-tumor
activity of curcumin on stomach cancer
You may have seen it popping up on cafe menus recently — the "golden
latte". It's hot milk mixed with turmeric, coconut oil, maybe a bit of
honey. Curcumin has been proclaimed a superfood; a health booster — the yellow
powder used as a central component in Asian cooking for thousands of years. turmeric was known as a healing food in
the ancient Indian system of medicine Ayurveda — where it was used for many
medical uses. Recently a new research indicates the curcumin also help prevent
or combat stomach cancer.
A recent study by researchers at
the Federal University of São Paulo (UNIFESP) and the Federal University of
Pará (UFPA) in Brazil identified possible therapeutic effects of this pigment
and of other bioactive compounds found in food on stomach cancer, the third and
fifth most frequent type of cancer among Brazilian men and women, respectively.
They undertook a vast review of the scientific literature on all nutrients and
bioactive compounds with the potential to prevent or treat stomach cancer and
found that curcumin is one of them. Curcumin is a natural regulator of histone
activity.
Histones are proteins in cell
nuclei that organize the DNA double helix into structural units called
nucleosomes. Each nucleosome is made of DNA coiled like a spool around eight
histone proteins (a histone octamer) to compact the DNA so that it fits in the
cell, where it is packaged into chromatin. The activity of the histones is regulated
by some enzymes like histone acetyltransferases (HATs) and histone deacetylases
(HDACs). These alterations are epigenetic and affect the structure and
integrity of the genome in many tumors, including stomach cancer.
The researchers have found that curcumin
influences histone modifications primarily by inhibiting HATs and HDACs to
suppress cancer cell proliferation and induce apoptosis (programmed cell
death) on the tumoral cells.
Journal Reference:
Danielle Q
Calcagno, Fernanda Wisnieski, Elizangela R da Silva Mota, Stefanie B Maia de
Sousa, Jéssica M Costa da Silva, Mariana F Leal, Carolina O Gigek, Leonardo C
Santos, Lucas T Rasmussen, Paulo P Assumpção, Rommel R Burbano, Marília AC
Smith. Role of histone acetylation in gastric cancer: implications of
dietetic compounds and clinical perspectives. Epigenomics, 2019; 11
(3): 349 DOI: 10.2217/epi-2018-0081
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