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Friday, 30 August 2013

CANCER INCREASES BANKRUPTCY RISK, EVEN FOR INSURED

Cancer patients are at much greater risk of bankruptcy than people without cancer, according to a large new study. And while the new health care law promises insurance coverage to more than 30 million Americans who lack it now, the high cost of cancer care can push many patients, especially younger women, into financial trouble, experts say.
“We need to look into why this happening and see if there is something we as a society can do to reduce that risk,” says Dr. Scott Ramsey, director of the Hutchinson Institute for Cancer Outcomes Research in Seattle and lead author of the study published Wednesday in the journal Health Affairs.
Ramsey and his colleagues matched 197,840 adults from a western Washington cancer registry with an equal number of cancer-free adults by age, zip code and sex. They then determined who had filed for bankruptcy, using court records.
The researchers found that 4,408 of those diagnosed with cancer between 1995 and 2009 had filed for bankruptcy, compared to 2,291 of those without cancer. Overall, cancer patients were 2.5 times as likely as others to file for bankruptcy.
Non-white females were the most likely to file, while patients 65 or older were the least likely -- possibly because they were covered by Medicare and eligible for Social Security.
Bankruptcy rates among the younger groups were up to 10 times that of the older patients. “People who have fewer assets, less income and less generous insurance because of entry level jobs or no insurance are more vulnerable to severe financial distress,” Ramsey says.
The highest rates of bankruptcy were among those with thyroid cancer, which mostly affects younger women. The lowest were in men with prostate cancer, which typically strikes at an older age.
“They used an ingenious way of getting this information,” says Dr. David Himmelstein, an internist and professor of public health at the City University of New York. And though the researchers don’t have information on the cancer patients’ insurance coverage, “previous studies tell us that about three-quarters of people who say that illness was a major factor in their bankruptcy had private health insurance, at least when they first got sick,” Himmelstein says.
That rings true for Janet Literski, 57, who had purchased health insurance as an independent contractor working in sales. When she was diagnosed with non-Hodgkin’s lymphoma in 2008 Literski discovered her insurance covered only part of her surgical costs and none of her diagnostic tests. Then there were co-payments and deductibles. By the time she was diagnosed with pancreatic cancer two years later, she was about $150,000 in medical debt.
In 2011, no longer able to work, Literski and her disabled husband filed for bankruptcy. “It was a gut wrenching decision because you feel like a personal failure, and that makes me angry because I had tried to do everything right,” Literski says. “I had health insurance, I was working.”
Literski is now covered by Medicaid and receives disability payments and though she hasn’t been told she’s in remission, she says she is “healthy enough.”
Ramsey says cancer centers need to do a better job of assessing each patient’s financial status, offering credit counseling, and managing patient care.
Steven Wieckowski, a financial counselor with the national nonprofit GreenPath Debt Solutions, advises newly diagnosed cancer patients to assess how the diagnosis might impact their income; to review their health insurance policy coverages; to determine whether they’re signed up for a disability plan at work; to prioritize their bills, putting housing, utilities, food, car payments and child care at the top of the list; and to reach out to credit card companies and the holders of student loans to ask for deferral.
“When cancer strikes, a lot of folks feel so out of control,” Wieckowski says. These steps can put people back into control of this portion of their life.”
Ramsey believes the 2010 Patient Protection and Affordable Care Act, which will extend health insurance coverage to more than 30 million Americans, could reduce bankruptcy rates.
But Himmelstein, who examined Massachusetts bankruptcy rates two years after the state implemented a health reform law similar to the federal law, isn’t hopeful.
“We found little or no impact, basically because the insurance coverage people got was so skimpy that it offered inadequate financial protection,” he says.
Source: NBC News Health


Tuesday, 27 August 2013

CAN A MENOPAUSAL HORMONE THERAPY CAUSE CANCER?

The Women’s Health Initiative study found that women taking combined hormone therapy (also called postmenopausal hormone therapy or hormone replacement therapy) to manage menopausal symptoms may have a higher risk of breast cancer. Combined hormone therapy is a combination of estrogen and progestin (a form of progesterone made in a laboratory). It is used to help women cope with menopausal symptoms and prevent osteoporosis. Hormone therapy with estrogen alone is only given to women who have had a hysterectomy (the removal of the uterus) because estrogen increases the risk of uterine cancer.
The Women’s Health Initiative also found that women taking combined hormone therapy had a higher risk of heart attack, stroke, and blood clots. However, they had a lower risk of colorectal cancer and bone fractures. Because of these risks, many doctors recommend that women do not take combined hormone therapy or only take low doses for a short time. Combined hormone therapy is not usually recommended for women with a history of breast cancer or those who have a higher risk of breast cancer.
Recent research also showed that women who received combined hormone therapy have a higher risk of dying of non-small cell lung cancer (NSCLC) if they develop the disease. However, woman in the study taking combined hormone therapy were not more likely to develop NSCLC than women who were not taking combined hormone therapy. The study also showed that the risk of dying from lung cancer was higher for women with NSCLC who smoke and take combined hormone therapy.
Research on combined hormone therapy is controversial and ongoing. The risks and benefits of the treatment are different for each woman. If you are considering hormone therapy for menopausal symptoms, it is important to talk with your doctor about your symptoms, medical history, and your options for relieving the symptoms, including the risks and benefits and how long you should take hormone therapy.

Source: Cancer.net web page

Saturday, 24 August 2013

CAN ORAL SEX CAUSE THROAT CANCER?

Michael Douglas was diagnosed with throat cancer (oropharyngeal cancer) three years ago. He initially said it was caused by years of heavy smoking, alcohol abuse and stress. However, he recently told The Guardian newspaper that it was caused by oral sex (cunnilingus).

In an Interview with Guardian reporter, Xan Brooks, Douglas said that his type of
cancer was caused by the human papillomavirus (HPV) "which actually comes from cunnilingus". His agent later said Douglas had been talking generally, and not about his own cancer, but the Guardian responded by publishing the sound recording of the interview that clearly showed he blamed oral sex for his cancer, and not years of drinking, smoking and stress.

Douglas first revealed details of his throat cancer in the David Letterman Show, in September 2010.
So, what is the risk of developing throat cancer from oral sex?
Gypsyamber D'Souza, PhD, MPH, from the Johns Hopkins School of Public Health, and team explained at the American Society of Clinical Oncology (ASCO) annual meeting in Chicago, Illinois, that throat cancers that arise from HPV do not appear to raise the risk for domestic partners of the same cancer.

Dr. D'Souza explained that in their pilot study, they found that the prevalence of HPV among partners/spouses of an affected patient was approximately 7%, no different from that of the general population.

The team found that the HPV 16 subtype was present in just 2% of female partners and 0% of male partners. HPV 16 is responsible for the majority of throat cancers. Of the partners/spouses who underwent a visual oral exam, none had cancer or pre-cancer.

D'Souza explained that the risk of developing head and neck cancers for people whose partners have HPV-related cancer is very low.

At a press briefing, D'Souza said "Many people become infected but are able to clear those infections."

The researchers added that partners who have been together for a long time probably already share whatever infections they have. No changes in physical intimacy are needed, they emphasized. Put more simply "Couples will infect each other with whatever they have anyway - oral sex will neither increase nor reduce infection risk".
Oral sex with 6 or more partners raises risk of throat cancer, said one study
In a study published in NEJM (New England Journal of Medicine), Dr Maura Gillison of Johns Hopkins Bloomberg School of Public Health in Baltimore, Maryland, USA, and team suggested that people who have oral sex with at least 6 different partners have a significantly higher risk of developing throat cancer.

The team recruited 100 patients who had recently been diagnosed with oropharyngeal cancer, as well as 200 "healthy" individuals (the control group).

They found that people who had at least 6 oral-sex partners during their lifetime were 3.4 times more likely to have throat cancer. Those with 26 or more vaginal-sex partners had a 3.1 times higher risk of developing throat cancer.
What are the risk factors for throat cancer?
Smoking - this is by far the most important risk factor for throat cancer. Regular, long-term, heavy smokers are 20 times more likely to develop some type of throat cancer compared to non-smokers.

Alcohol - heavy, chronic alcohol consumption, particularly spirits, also raises the risk of developing throat cancer.

People who do both - drink and smoke a lot - have the highest risk.

Frequent heartburn -
non-drinkers and non-smokers who have frequent heartburn have a higher risk of developing cancers of the throat and vocal cord.


Source: Medical News Today

Thursday, 15 August 2013

ANTI-CANCER DRUG REVERSES ALZHEIMER´S DISEASE IN MICE


The study, published in the journal Science, examined previously published outcomes on the drug bexarotene - which is approved by the U.S. Food and Drug Administration for use in cutaneous T cell lymphoma.
The researchers established that the drug does notably improve cognitive deficits in mice expressing gene mutations associated with human Alzheimer's disease, however, they could not verify the effect on amyloid plaques.
Senior author Rada Koldamova, M.D., Ph.D., associate professor in Pitt Public Health's Department of Environmental and Occupational Health, said, "We believe these findings make a solid case for continued exploration of bexarotene as a therapeutic treatment for Alzheimer's disease."
Dr. Koldamova and her team were studying mice expressing human Apolipoprotein E4 (APOE4) - the only known genetic risk factor for late-onset Alzheimer's disease, or APOE3 - known not to raise the risk for Alzheimer's disease - when a Case Western Reserve University study was published last year.
It claimed that bexarotene elevates memory and rapidly cleared amyloid plaques from the brains of Alzheimer's model mice expressing mouse Apolipoprotein E (APOE).
Amyloid plaques are made up of toxic protein fragments known as amyloid beta that are known to damage neurons in the brain and are believed to result in the memory deficits linked to Alzheimer's disease, and eventually death.
Bexarotene is a compound chemically associated with vitamin A that triggers Retinoic X Receptors (RXR) found all over the body including neurons and other brain cells. Once they are activated, the receptors bind to DNA and control the expression of genes that guide many different biological functions.
Elevated levels of APOE are one result of RXR activations by bexarotene. The researchers started examining similar compounds over 10 years ago.
Source: Medical News Today

Tuesday, 6 August 2013

OMEGA-3 ROLE IN PREVENTING ORAL AND SKIN CANCERS

Foods containing omega-3 fatty acids may help in the prevention of early- and late-stage oral and skin cancers, according to a study published in the journal Carcinogenesis.
UK researchers from Queen Mary, University of London grew cell cultures in the laboratory from several different cell lines. These included both malignant oral and skin cancers, alongside pre-malignant cells and normal skin and oral cells.
The focus was mainly on a type of cancer called squamous-cell carcinoma. This is one of the major forms of skin cancer affecting the outer layers of the skin (mainly made up of squamous cells). The researchers point out that squamous-cell carcinoma can also occur in the lining of the digestive tract, lungs and other areas of the body.
Oral squamous cell carcinomas are the sixth most common skin cancer worldwide, the researchers say, and are difficult and expensive to treat.
Omega-3 induced cancer cell death
When the researchers carried out in vitro tests by adding fatty acids into the cell cultures, results showed that omega-3 fatty acids induced cell death in malignant and pre-malignant cells in doses that did not affect normal cells.
Professor Kenneth Parkinson, head of the oral cancer research group at Queen Mary's Institute of Dentistry, says:
"We found that the omega-3 fatty acid selectively inhibited the growth of the malignant and pre-malignant cells at doses which did not affect the normal cells."
"Surprisingly, we discovered this was partly due to an over-stimulation of a key growth factor (epidermal growth factor) which triggered cell death. This is a novel mechanism of action of these fatty acids," Prof. Parkinson adds.
Potential cure for oral and skin cancers?
The scientists say that because the doses needed to kill the cancer cells did not affect normal cells, this means Omega-3 fatty acids could be used for the prevention and treatment of oral and skin cancers.
Omega-3 polyunsaturated fatty acids are found mainly in oily, fatty fish. Previous research has found that omega-3 may have numerous health benefits, including helping to prevent cardiovascular disease.
Research from the University of Pittsburgh has also suggested that high consumption of the fatty acids can improve memory in young adults.
Increasing omega-3 levels 'may reduce cancer risk'
Because omega-3 cannot be made in large quantities by the human body, the main way to increase levels is to consume foods that are rich in it. Advice on fish and omega-3 fatty acids from the American Heart Association recommends at least two servings (3.5 ounces for each) of oily fish every week.
Many other foods also contain high levels of omega-3, including:
·         Salmon
·         Walnuts
·         Ground flax seeds
·         Sardines
·         Beef (from grass-fed cows)
·         Soybeans
·         Halibut
·         Scallops
·         Shrimp
·         Tofu.
Source: Medical News today